I never thought a role model should be negative.
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There were plenty of role models for us. My mother believed in education and she put all three of us through college at Grambling. She did not have a high school education, but it was something she impressed upon us. After I graduated, I left Texarkana for California, because I knew I could not get a job here. I was in business with certification and accounting, so I figured it was best to go out West. So I went there. It was still tough to get in that field, but things opened up for me.
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Celebrity-worship and hero-worship should not be confused. Yet we confuse them every day, and by doing so we come dangerously close to depriving ourselves of all real models. We lose sight of the men and women who do not simply seem great because they are famous but are famous because they are great. We come closer and closer to degrading all fame into notoriety.
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Culture is the name for what people are interested in, their thoughts, their models, the books they read and the speeches they hear, their table-talk, gossip, controversies, historical sense and scientific training, the values they appreciate, the quality of life they admire. All communities have a culture. It is the climate of their civilization.
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I've never been to New Zealand before. But one of my role models, Xena, the warrior princess, comes from there.
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After massive blood loss a dog's intestines are congested, while in humans we see pallor and ischemia. No wonder conclusions from dog experiments extrapolated to human beings frequently brings about catastrophic results and regrettable failures, which occurred with the earlier models of heart valves and in the first several years of using the heart-lung machine. For the benefit of medical science vivisection should be stopped. We must put an end to the medical fraud of vivisection.'
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Who's most likely to buy our products, who's least likely to buy them and who's up for grabs. This has given us a much deeper insight than we've ever had before using traditional demographic or vehicle segment-based models. One of the most important findings from this research is that there remains a huge market for American cars in this country. And the potential is significantly larger than the roughly 55 percent market share than GM, Ford and Chrysler together command today.
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In the U.S. NCI retrospective (2001), activity in at least 33% of models of a variety of histologies predicted for clinical activity in some disease. In the NCI of Canada retrospective (2003), generally similar conclusions were reached. It should be cautioned, however, that the drugs used in these studies were for the most part 'classic' cytotoxics. Whether 'targeted' therapeutics, such as signal transduction inhibitors, antiangiogenic, or stroma-modifying agents, would perform better or worse remains to be defined.
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Men nearly always follow the tracks made by others and proceed in their affairs by imitation, even though they cannot entirely keep to the tracks of others or emulate the prowess of their models. So a prudent man should always follow in the footsteps of great men and imitate those who have been outstanding. If his own prowess fails to compare with theirs, at least it has an air of greatness about it. He should behave like those archers who, if they are skilful, when the target seems too distant, know the capabilities of their bow and aim a good deal higher than their objective, not in order to shoot so high but so that by aiming high they can reach the target.
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Our risk models are based on at least 50 assumptions, none of which has been scientifically demonstrated. For example, we assume that there is no difference between continuous (as in animal tests) or intermittent (as in human experience) dosages. But that ignores our growing knowledge of the way in which DNA repairs the human system . . .We feed rodents `all-you-can-eat' buffets every day, yet we know that caloric intake is the single greatest contributing cause of cancer [in rodents]. In fact, we found you can modify the cancer causing impact of one of the most potent carcinogens from 90% down to less than 3%, just by cutting caloric intake 20%.
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There are many methods for predicting the future. For example, you can read horoscopes, tea leaves, tarot cards, or crystal balls. Collectively, these methods are known as 'nutty methods.' Or you can put well-researched facts into sophisticated computer models, more commonly referred to as a complete waste of time.
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There are many methods for predicting the future. For example, you can read horoscopes, tea leaves, tarot cards, or crystal balls. Collectively, these methods are known as 'nutty methods.' Or you can put well-researched facts into sophisticated computer models, more commonly referred to as 'a complete waste of time.'
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It cannot suffice to invent new machines, new regulations, new institutions. It is necessary to change and improve our understanding of the true purpose of what we are and what we do in the world. Only such a new understanding will allow us to develop new models of behavior, new scales of values and goals, and thereby invest the global regulations, treaties and institutions with a new spirit and meaning.
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Today it is not the classroom nor the classics which are the repositories of models of eloquence, but the ad agencies.
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For 39 agents with both xenograft data and Phase II clinical trials results available, in vivo activity in a particular histology in a tumour model did not closely correlate with activity in the same human cancer histology, casting doubt on the correspondence of the pre-clinical models to clinical results.
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Even when drugs with evidence of anticancer activity in preclinical in vivo models are given at their maximum tolerated doses, they frequently fail to produce useful activity in humans.
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The discovery of chemotherapeutic agents for the treatment of human cancer is widely heralded as a triumph due to the use of animal models… However, there is little, if any, factual evidence that would support these claims… Indeed, while conflicting animal results have often delayed and hampered advances in the war on cancer, they have never produced a single substantial advance in either the prevention or treatment of human cancer.
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It’s been well known for maybe two decades that many of these preclinical human cancer models have very little predictive power in terms of how actual human beings – actual human tumours inside patients – will respond…Preclinical models of human cancer, in large part, stink…Hundreds of millions of dollars are being wasted every year by drug companies using these [animal] models…
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In summary, mouse xenograft models should not be viewed as ideal models for cancer drug development. Altered, nonhuman host stroma, poor predictive value when applied in an empirical sense, and questionable relation to the naturally occurring human disease are but a few features, which temper enthusiasm for their use.
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The principal method of determining potential carcinogenicity of substances is based on studies of daily administration of huge doses of chemicals to inbred rodents for a lifetime. Then by questionable models, which include large safety factors, the results are extrapolated to effects of minuscule doses in humans... The rodent MTD test that labels plant chemicals as cancer-causing in humans is misleading. The test is likewise of limited value for synthetic chemicals. The standard carcinogen tests that use rodents are an obsolescent relic of the ignorance of past decades.
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There is a breed of fashion models who weigh no more than an abridged dictionary.
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The sciences do not try to explain, they hardly even try to interpret, they mainly make models. By a model is meant a mathematical construct which, with the addition of certain verbal interpretations, describes observed phenomena. The justification of such a mathematical construct is solely and precisely that it is expected to work.
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We blacks look for leadership in men and women of such youth and inexperience, as well as poverty of education and character, that it is no wonder that we sometimes seem rudderless. . . . We see basketball players and pop singers as possible role models.
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We boast our emancipation from many superstitions; but if we have broken any idols, it is through a transfer of idolatry.
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I couldn't quit, because of all the kids, and the blacks, and the little people pulling for me. I represent both the underdog and the overdog in our society.
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Data from dose-response relationships are sometimes employed to estimate the expected tumour incidence at dose levels very much lower than those which could possibly be employed in conventional [animal] experiments. A number of mathematical models have been employed in such estimates and the results obtained vary considerably. Despite these uncertainties - and the possibly greater ones in extrapolating from animals to man - such models are often employed in some quarters to estimate the likely risk to man.
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We are delighted with Ford's success in 2005. Although the industry as a whole is growing, trading conditions are still extremely competitive with greater variety of models now on offer.
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It motivated the players to have women role models. They could go to the Target Center and watch the (WNBA's Minnesota) Lynx play, ... They could have heroes like Rebecca Lobo and those other great UConn players. They wanted to be like them. As a coach you just give them the skills needed for the opportunity to make it some day.
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The small progress we have made after four or five weeks close attendance and continual reasonings with each other is, methinks, a melancholy proof of the imperfection of the human understanding. We indeed seem to feel our own want of political wisdom, since we have been running about in search of it. We have gone back to ancient history for models of government, and examined the different forms of those republics which, having been formed with seeds of their own dissolution, now no longer exist.
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We will discover the nature of our particular genius when we stop trying to conform to our own or to other peoples' models, learn to be ourselves, and allow our natural channel to open.
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