Your mother is a hamster and your father smelt of elderberries... now go away before I taunt you a second time!
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…one of the great fallacies in this calculation is that they are assuming that the mouse or rat or the hamster predicts for man, and we have no basis for this prediction…So it’s again a half-baked guess… Does the animal model have any relevance to human disease? If not we’re wasting a lot of time, a lot of money, a lot of good scientists, and a lot of good space at NIH… I completely agree with Dr. Clayton that extrapolation is unscientific… the chief objective here is to keep us all employed and to make sure we do interesting experiments so we can keep coming back to nice places like this.
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[Regarding tamoxifen, an anti-cancer drug] 'Experimentally, tamoxifen has carcinogenic potential. In some strains of rat, but not mouse or hamster, tamoxifen can cause liver cancers at doses as low as 5mg/kg per day... However, there are doubts about the correlation of [the results] with the risk of malignant disease even in rats, let alone in other rodents, mammals, or human beings. There are many uncertainties in extrapolating these experimental data from rats to women. The effect depends on bioavailability, hepatic [liver] blood flow, and hepatic [liver] metabolism to active genotoxic carcinogens, all of which differ enormously between rat and man.
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