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…one of the great fallacies in this calculation is that they are assuming that the mouse or rat or the hamster predicts for man, and we have no basis for this prediction…So it’s again a half-baked guess… Does the animal model have any relevance to human disease? If not we’re wasting a lot of time, a lot of money, a lot of good scientists, and a lot of good space at NIH… I completely agree with Dr. Clayton that extrapolation is unscientific… the chief objective here is to keep us all employed and to make sure we do interesting experiments so we can keep coming back to nice places like this.

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We have a discrepancy between animal data and human data…clearly, right now our animal models are totally and absolutely inadequate to answer all the obvious questions before us.

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