Our true history is scarcely ever deciphered by others. The chief part of the drama is a monologue, or rather an intimate debate between God, our conscience, and ourselves. Tears, grieves, depressions, disappointments, irritations, good and evil thoughts, decisions, uncertainties, deliberations --all these belong to our secret, and are almost all incommunicable and intransmissible, even when we try to speak of them, and even when we write them down.
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Data from dose-response relationships are sometimes employed to estimate the expected tumour incidence at dose levels very much lower than those which could possibly be employed in conventional [animal] experiments. A number of mathematical models have been employed in such estimates and the results obtained vary considerably. Despite these uncertainties - and the possibly greater ones in extrapolating from animals to man - such models are often employed in some quarters to estimate the likely risk to man.
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The Fed has and must have a commitment to price stability, ... The uncertainties on the upside (for inflation) have only gotten bigger since Katrina slammed into the Gulf Coast.
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[Regarding tamoxifen, an anti-cancer drug] 'Experimentally, tamoxifen has carcinogenic potential. In some strains of rat, but not mouse or hamster, tamoxifen can cause liver cancers at doses as low as 5mg/kg per day... However, there are doubts about the correlation of [the results] with the risk of malignant disease even in rats, let alone in other rodents, mammals, or human beings. There are many uncertainties in extrapolating these experimental data from rats to women. The effect depends on bioavailability, hepatic [liver] blood flow, and hepatic [liver] metabolism to active genotoxic carcinogens, all of which differ enormously between rat and man.
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So what do we do? Anything. Something. So long as we just don't sit there. If we screw it up, start over. Try something else. If we wait until we've satisfied all the uncertainties, it may be too late.
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