[n] the act of troubling or annoying someone
[n] something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
[n] anger produced by some annoying irritation
[n] an unpleasant person who is annoying or exasperating
[n] the psychological state of being irritated or annoyed