[n] something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
[n] the psychological state of being irritated or annoyed
bummer, huff, impatience, irritant, mental state, miff, negative stimulus, nuisance, pinprick, plague, psychological state, restlessness, seeing red, snit, thorn
\Both`er*a"tion\, n. The act of bothering, or state of being bothered; cause of trouble; perplexity; annoyance; vexation. [Colloq.]