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In the U.S. NCI retrospective (2001), activity in at least 33% of models of a variety of histologies predicted for clinical activity in some disease. In the NCI of Canada retrospective (2003), generally similar conclusions were reached. It should be cautioned, however, that the drugs used in these studies were for the most part 'classic' cytotoxics. Whether 'targeted' therapeutics, such as signal transduction inhibitors, antiangiogenic, or stroma-modifying agents, would perform better or worse remains to be defined.

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