The summer day is closed - the sun is set: Well they have done their office, those bright hours, The latest of whose train goes softly out In the red west. The green blade of the ground Has risen, and herds have cropped it; the young twig Has spread its plaited tissues to the sun; Flowers of the garden and the waste have blown And withered; seeds have fallen upon the soil, From bursting cells, and in their graves await Their resurrection. Insects from the pools Have filled the air awhile with humming wings, That now are still for ever; painted moths Have wandered the blue sky, and died again
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The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.
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Our goals were to address the following, ... Does ascorbate in pharmacologic concentrations kill cancer cells, but not normal cells, using conditions that mimic IV use and a clinically relevant time course? Is action dependent on extracellular ascorbate, intracellular ascorbate, or both? If effective, what are the mechanisms? Can ascorbate be delivered to tissues without harm? Are there implications for other diseases?
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The tendinous part of the mind, so to speak, is more developed in winter the fleshy, in summer. I should say winter had given the bone and sinew to literature, summer the tissues and the blood.
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The tendinous part of the mind, so to speak, is more developed in winter; the fleshy, in summer. I should say winter had given the bone and sinew to literature, summer the tissues and the blood.
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Elsewhere, I have pointed out that overfeeding of rats profoundly influences the incidence particularly of endocrine tumours. Furthermore, endocrine tumours and tumours of tissues, such as the breast and uterus, which are very directly under sex-hormone control, constitute a very high proportion of the tumours observed in most carcinogenicity studies in rats. [Comparing] the incidences of tumours in these categories in men and women with those in male and female rats... [shows] the differences between the two species are sufficiently striking to make one wonder how appropriate the laboratory rat is as a model for man in terms of the spectra of tumours to which they are prone.
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