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In the U.S. NCI retrospective (2001), activity in at least 33% of models of a variety of histologies predicted for clinical activity in some disease. In the NCI of Canada retrospective (2003), generally similar conclusions were reached. It should be cautioned, however, that the drugs used in these studies were for the most part 'classic' cytotoxics. Whether 'targeted' therapeutics, such as signal transduction inhibitors, antiangiogenic, or stroma-modifying agents, would perform better or worse remains to be defined.

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The new system which is being employed at the Development Therapeutics Programme in Frederick, Maryland, uses an arsenal of automated devices and computers to test potential cancer-fighting drugs on real human cancer cells grown in laboratories rather than on mice. This enables scientists to test more than 300 chemicals a week. Many of these drugs had failed in the past when tested on mice.'

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