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It is in fact hard to find a single, common solid neoplasm [cancer] where management and expectation of cure has been markedly affected by animal research. Most human cancers differ from the artificially produced animal model

+Fav | Go to Quote / Comment | Harrison |

It has been conventional practice to test potential carcinogens using highly inbred strains of rodents. The rationale was the supposed superior reproducibility of results compared with those obtained from wild-type animals. However, that assumption can be questioned. At least three examples of genetic drift of inbred strains can be cited... Lifetime expectation [in an inbred strain of mice] of developing one or another form of neoplasm ['spontaneous tumour'] had risen from 10 to 80 percent.

+Fav | Go to Quote / Comment | Philip H Abelson |