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The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.

+Fav | Go to Quote / Comment | Alan Oliff |

In summary, mouse xenograft models should not be viewed as ideal models for cancer drug development. Altered, nonhuman host stroma, poor predictive value when applied in an empirical sense, and questionable relation to the naturally occurring human disease are but a few features, which temper enthusiasm for their use.

+Fav | Go to Quote / Comment | Sausville and Burger |