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Our goals were to address the following, ... Does ascorbate in pharmacologic concentrations kill cancer cells, but not normal cells, using conditions that mimic IV use and a clinically relevant time course? Is action dependent on extracellular ascorbate, intracellular ascorbate, or both? If effective, what are the mechanisms? Can ascorbate be delivered to tissues without harm? Are there implications for other diseases?

+Fav | Go to Quote / Comment | Mark Levine |

[mouse models are] woefully inadequate…if you look at the millions and millions and millions of mice that have been cured, and you compare that to the relative success, or lack thereof, that we've achieved in the treatment of metastatic disease clinically, you realize that there just has to be something wrong with those models.

+Fav | Go to Quote / Comment | Homer Pearce |