[n] action that makes a problem or a disease (or its symptoms) worse; "the aggravation of her condition resulted from lack of care" [n] unfriendly behavior that causes anger or resentment [n] an exasperated feeling of annoyance
exacerbation, exasperation, irritation, provocation
accelerando, acceleration, adverse circumstances, adversity, affliction, agitation, animation, annoyance, annoyingness, arousal, arousing, bad news, bedevilment, beefing-up, blight, blowing up, blowup, bore, bother, botheration, bothersomeness, bummer, ca