'In the bad old days reference to Blacks/women/Jews/others were in negative language which perpetuated poor treatment/ abuse/ exploitation of these people. Animals have suffered more from negative language stereotyping than all the others, and demeans them so constantly that they created an environment that allows all sorts of cruelties, many too horrendous to describe! An animal is 'it' instead of 'he' or 'she', this perpetuates our view of them as 'things' rather than individuals and is a major first step towards cutting them up for meat and leather, testing drugs/cosmetics/ household products on their bodies, and tearing off their coats for furs!!! Those who have pets are referred to as 'owners' rather than guardians/care givers/companions, reinforcing the idea that they are property much as slaves were considered property. Let's avoid these references: Dirty rat; filthy pig; acting like an ass; dirty dog; she's a bitch; ugly duckling; there's more than one way to skin a cat; behaving like an animal; making a monkey out of someone; killing 2 birds with one stone; working like a horse, you're chicken ... There are many more! Please think before uttering them and tell others. Thank you!'
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Mickey Mouse to a three-year-old is a six-foot-tall RAT!
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And my poor fool is hanged! No, no, no life! Why should a dog, a horse, a rat have life,...
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1-3 Butadiene, an important industrial chemical and a common environmental air pollutant, has been shown to be a weak carcinogen in the rat, but a potent carcinogen in the B6C3F1 mouse. This species difference makes risk extrapolation to humans difficult, and the underlying mechanism must be clarified before meaningful risk extrapolation to humans can be made.
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People need trouble -- a little frustration to sharpen the spirit on, toughen it. Artists do; I don't mean you need to live in a rat hole or gutter, but you have to learn fortitude, endurance. Only vegetables are happy.
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By gnawing through a dike, even a rat may drown a nation.
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Humor, a good sense of it, is to Americans what manhood is to Spaniards and we will go to great lengths to prove it. Experiments with laboratory rats have shown that, if one psychologist in the room laughs at something a rat does, all of the other psychologists in the room will laugh equally. Nobody wants to be left holding the joke.
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... numerous chemicals have been found to have potential toxicity/carcinogenicity in rat or mouse, which, we are reasonably certain, have little or no potential hazard in man. The reason for this is again species differences, for the biological defence mechanism which protects against toxic chemicals is most highly evolved in man, who therefore generally has a higher resistance to chemical toxicity and carcinogenicity than have rodents and other species.
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Up a narrow flight of stairs In a narrow little room, As I lie upon my bed In the early evening gloom. Impaled on my wall My eyes can dimly see The pattern of my life And the puzzle that is me.
From the moment of my birth To the instant of my death, There are patterns I must follow Just as I must breathe each breath. Like a rat in a maze The path before me lies, And the pattern never alters Until the rat dies.
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When it comes to having a central nervous system, and the ability to feel pain, hunger, and thirst, a rat is a pig is a dog is a boy.
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It is restful, tragedy, because one knows that there is no more lousy hope left. You know you're caught, caught at last like a rat with all the world on its back. And the only thing left to do is shout -- not moan, or complain, but yell out at the top of your voice whatever it was you had to say. What you've never said before. What perhaps you don't even know till now.
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Hating people is like burning down your house to get rid of a rat.
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A cross between an aardvark and an albino rat.
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Fate is not an eagle, it creeps like a rat.
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Elsewhere, I have pointed out that overfeeding of rats profoundly influences the incidence particularly of endocrine tumours. Furthermore, endocrine tumours and tumours of tissues, such as the breast and uterus, which are very directly under sex-hormone control, constitute a very high proportion of the tumours observed in most carcinogenicity studies in rats. [Comparing] the incidences of tumours in these categories in men and women with those in male and female rats... [shows] the differences between the two species are sufficiently striking to make one wonder how appropriate the laboratory rat is as a model for man in terms of the spectra of tumours to which they are prone.
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The standard carcinogenicity bioassay, which involves treating two rodent species for a minimum of 2 years, at a range of doses, is acknowledged to be an insensitive tool because of the background `noise' of spontaneous disease. Most strains of rat used in such studies have high incidence of pituitary and mammary tumours; some inbred rat strains frequently develop leukaemia or testicular tumours; mice strains show high incidence of malignant lymphomas and liver tumours.
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Mickey Mouse is a rat.
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A rat crept softly through the vegetation Dragging its slimy belly on the bank...
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It is one thing to decry the rat race...that is the good and honorable work of moralists. It is quite another thing to quit the rat race, to drop out, to refuse to run any further--that is the work of the individualist. It is offensive because it is impolite it makes the rebuke personal the individualist calls not his or her behavior into question, but mine.
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You can drop a mouse down a thousand-yard mine shaft and, on arriving at the bottom, it gets a slight shock and walks away. A rat would probably be killed, though it can fall safely from the eleventh story of a building, a man is broken, a horse splashes.
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[Regarding tamoxifen, an anti-cancer drug] 'Experimentally, tamoxifen has carcinogenic potential. In some strains of rat, but not mouse or hamster, tamoxifen can cause liver cancers at doses as low as 5mg/kg per day... However, there are doubts about the correlation of [the results] with the risk of malignant disease even in rats, let alone in other rodents, mammals, or human beings. There are many uncertainties in extrapolating these experimental data from rats to women. The effect depends on bioavailability, hepatic [liver] blood flow, and hepatic [liver] metabolism to active genotoxic carcinogens, all of which differ enormously between rat and man.
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The trouble with the rat-race is that even if you win, you're still a rat.
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The trouble with the rat race is that even if you win, you're still a rat.
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…one of the great fallacies in this calculation is that they are assuming that the mouse or rat or the hamster predicts for man, and we have no basis for this prediction…So it’s again a half-baked guess… Does the animal model have any relevance to human disease? If not we’re wasting a lot of time, a lot of money, a lot of good scientists, and a lot of good space at NIH… I completely agree with Dr. Clayton that extrapolation is unscientific… the chief objective here is to keep us all employed and to make sure we do interesting experiments so we can keep coming back to nice places like this.
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Never rat on your friends and always keep your mouth shut!
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'A drug is a substance that, when injected into a rat, produces a scientific paper.'
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The trouble with the rat race is that even if you win you're still a rat.
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The characteristic effects in leukaemia were detected solely as a result of clinical observation. The various leukaemias in the mouse and rat were relatively refractory to the influence of urethane, and the remarkable effect in the human might have eluded discovery if attention had been directed to the animal alone. That illustrates the hazards of such work.
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A squirrel is just a rat with a cuter outfit!
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I'm grateful to you. If it weren't for you, I'd be in Cicely right now and I'd still be running that rat race, still locked in that commute. I'd be totally stressed, I'd be totally ignorant of what my life could be. I'm happier now than I've ever been.
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