[n] one the first colonists or settler in a new territory; "they went west as pioneers with only the possessions they could carry with them"
[n] someone who helps to open up a new line of research or technology or art
[v] take the lead or initiative in; participate in the development of; "This South African surgeon pioneered heart transplants"
[v] open up an area or prepare a way; "She pioneered a graduate program for women students"
activate, actuate, arrange, attempt, backwoodsman, Bowie, bring about, bushman, cause, Chapman, colonist, conceiver, constitute, devise, do, establish, found, frontiersman, frontierswoman, get up, innovate, institute, introduce, James Bowie, John Chapman, Johnny Appleseed, launch, machinate, make, mastermind, mount, mountain man, organise, organize, originator, plant, prepare, set about, set off, settler, spark, spark off, stage, strike up, touch off, trigger, trigger off, trip, undertake