[n] a small hard painless nodule at the site of entry of a pathogen (as syphilis)
abscess, acquired syphilis, aposteme, balanitis gangrenosa, bed sore, blain, bleb, blister, boil, bubo, bulla, bunion, canker, canker sore, carbuncle, cerebral tabes, chancroid, chilblain, clap, claps, climatic bubo, cold sore, congenital syphilis, consti