It is one of the severest tests of friendship to tell your friend his faults. So to love a man that you cannot bear to see a stain upon him, and to speak painful truth through loving words, that is friendship.
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Peace hath higher tests of manhood than battle ever knew.
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Getting ahead in a difficult profession -- singing, acting, writing, whatever -- requires avid faith in yourself. You must be able to sustain yourself against staggering blows and unfair reversals. When I think back to those first couple of years in Rome, those endless rejections, without a glimmer of encouragement from anyone, all those failed screen tests, and yet I never let my desire slide away from me, my belief in myself and what I felt I could achieve.
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It is not the literal past that rules us, save, possibly, in a biological sense. It is images of the past. Each new historical era mirrors itself in the picture and active mythology of its past or of a past borrowed from other cultures. It tests its sense of identity, of regress or new achievement against that past.
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Aside from all that, we recall that antibodies to malaria and other diseases prevalent in Africa show up as HIV-positive on tests.
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Each new historical era mirrors itself in the picture and archive mythology of its past or of a past borrowed from other cultures. It tests its sense of identity, of regress or new achievement, against that past.
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Suppose that humans happen to be so constructed that they desire the opportunity for freely undertaken productive work. Suppose that they want to be free from the meddling of technocrats and commissars, bankers and tycoons, mad bombers who engage in psychological tests of will with peasants defending their homes, behavioral scientists who can't tell a pigeon from a poet, or anyone else who tries to wish freedom and dignity out of existence or beat them into oblivion.
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'The drugs Prednisone and Vincristine are often hailed as 'curing' childhood leukemia. Both drugs were rejected by the US National Cancer Institute as 'useless' on the basis of animal tests. Prednisone was developed as a result of clinical observation of the effects of adrenal extract. Vincristine is an alkaloid of 'Vincra Rosea', a type of periwinkle plant, and extracts of periwinkle were used in the Roman Empire to 'dry tumours' (Pliny). They were eventually brought to clinical trials. The children cured of leukemia owe their lives to clinical observations and trials - and not to the animal 'model'.'
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According to Dr Ray Greek: 'Most pharmaceutical firms do more testing than the government requires, so they can say in court that they saw no effects like the one that killed the plaintiff's wife. Officials will tell you off the record that they rely on animal testing and think that it is a big factor in protection from lawsuits.' Or, the companies can turn around and dismiss the animal tests as being unreliable in humans. Either way, it is extremely hard for victims to take legal action against them.
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CONCLUSION ON DRUG TESTING The inescapable conclusion is that drug companies choose animal tests over scientific methods because of the utter unreliability of animal tests. Because each animal species is unique in its physiological, biochemical, histological, morphological and other characteristics, and consequently reacts differently to substances, drug companies can produce results favourable to their interests by simply choosing the appropriate species.
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Our risk models are based on at least 50 assumptions, none of which has been scientifically demonstrated. For example, we assume that there is no difference between continuous (as in animal tests) or intermittent (as in human experience) dosages. But that ignores our growing knowledge of the way in which DNA repairs the human system . . .We feed rodents `all-you-can-eat' buffets every day, yet we know that caloric intake is the single greatest contributing cause of cancer [in rodents]. In fact, we found you can modify the cancer causing impact of one of the most potent carcinogens from 90% down to less than 3%, just by cutting caloric intake 20%.
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Why the dog was ever considered as an appropriate animal for carcinogenicity testing is also not entirely clear... Despite the obvious problems of study design and interpretation, carcinogenicity tests in the dog, lasting 7 years, were requested by regulatory authorities from the late 1960s...One of the best known examples of the inappropriate use of the dog was the carcinogenicity testing of hormonal contraceptives. It is now understood that mammogenesis in the dog is very different from that in primates; quantitative and qualitative differences exist in the feedback control mechanisms, receptor content and behaviour, and target sensitivity and responsivity. As a result of this biological difference there was a high incidence of mammary tumours in long-term studies in dogs treated with progestagens/contraceptive steroids such as lynestrol. Ultimately pressure from the scientific community led, relatively recently, to the requirement for carcinogenicity studies in dogs being dropped.
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The secret of a leader lies in the tests he has faced over the whole course of his life and the habit of action he develops in meeting those tests.
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For all his self-serving lie-detector tests, now and whatever else his lawyer spins in his favor, it will not erase the fact he misled and misled badly the lawful conduct of a police investigation.
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The principal method of determining potential carcinogenicity of substances is based on studies of daily administration of huge doses of chemicals to inbred rodents for a lifetime. Then by questionable models, which include large safety factors, the results are extrapolated to effects of minuscule doses in humans... The rodent MTD test that labels plant chemicals as cancer-causing in humans is misleading. The test is likewise of limited value for synthetic chemicals. The standard carcinogen tests that use rodents are an obsolescent relic of the ignorance of past decades.
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Only a fool tests the depth of the water with both feet.
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Every year tens of thousands of animals suffer and die in laboratory tests of cosmetics and household products...despite the fact that the test results do not help prevent or treat accidental or purposeful misuse of the products. Please join me in using your voice for those whose cries are forever sealed behind the laboratory doors.
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There is no discipline in the world so severe as the discipline of experience subjected to the tests of intelligent development and direction.
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I know hundreds of people who have spent years and thousands of dollars on tests looking for ulcers or spastic bowels. I tell them to lay off all dairy products for two weeks. The results are usually so striking that it changes thier lives.
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Those who actually set out to see the fall of a city or those who choose to go to a front line, are obviously asking themselves to what extent they are cowards. But the tests they set themselves -- there is a dead body, can you bear to look at it? -- are nothing in comparison with the tests that are sprung on them. It is not the obvious tests that matter (do you go to pieces in a mortar attack?) but the unexpected ones (here is a man on the run, seeking your help -- can you face him honestly?).
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The nine-tenths prove man's love, but the one-tenth tests man's legal obedience.
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There have been studies that clearly state that children who are exposed to arts education at a young age will in fact do markedly better in their SAT tests.
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The United States strongly seeks a lasting agreement for the discontinuance of nuclear weapons tests. We believe that this would be an important step toward reduction of international tensions and would open the way to further agreement on substantial measures of disarmament.
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We commissioned additional tests on more samples of the stem cells featured on the 2004 Science article.
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Results from animal tests are not transferable between species, and therefore cannot guarantee product safety for humans...In reality these tests do not provide protection for consumers from unsafe products, but rather they are used to protect corporations from legal liability.
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The principle of majority rule is the mildest form in which the force of numbers can be exercised. It is a pacific substitute for civil war in which the opposing armies are counted and the victory is awarded to the larger before any blood is shed. Except in the sacred tests of democracy and in the incantations of the orators, we hardly take the trouble to pretend that the rule of the majority is not at bottom a rule of force.
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One of the tests of leadership is the ability to recognize a problem before it becomes an emergency.
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At college age, you can tell who is best at taking tests and going to school, but you can't tell who the best people are. That worries the hell out of me.
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The problem with animal carcinogenicity tests is not their lack of sensitivity for human carcinogens, but rather their lack of human specificity. A positive result has poor predictive value for humans.
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Arsenic sticks around and today it's easily found after death if somebody thinks of looking for it, because the problem with arsenic, it isn't looked for in the common tests for drugs.
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