The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.
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Poorly secured nuclear material in the former Soviet Union, or secrets from a scientist in Pakistan could help build a bomb that detonates in Paris. The poppies in Afghanistan become the heroin in Berlin. The poverty and violence in Somalia breeds the terror of tomorrow.
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True, what you sacrifice for the world is but poorly recognized by it; for it is man that rules and reaps the harvest; the thousand night watches and sacrifices by which a mother secures the state a hero or a poet are forgotten, not even mentioned, for the mother herself does not mention them, and so one century after another do the wives, unknown and unrewarded send forth the arrows, the starts the storm-birds and the nightingales of time.
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No matter under what circumstances you leave it, home does not cease to be home. No matter how you lived there-well or poorly.
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When I hear so much impatient and irritable complaint, so much readiness to replace what we have by guardians for us all, those supermen, evoked somewhere from the clouds, whom none have seen and none are ready to name, I lapse into a dream... I see children playing on the grass, ...they are restive and quarrelsome; they cannot agree to any common plan; their play annoys them; it goes poorly. And one says, let us make Jack the master; Jack knows all about it; Jack will tell us what each is to do and we shall all agree. But Jack is like all the rest; Helen is discontented with her part and Henry with his, and soon they fall again into their old state. No, the children must learn to play by themselves; there is no Jack the master. And in the end slowly and with infinite disappointment they do learn a little; they learn to forbear, to reckon with anther, accept a little where they wanted much, to live and let live, to yield when they must yield; perhaps, we may hope, not to take all they can. But the condition is that they shall be willing at least to listen to one another, to get the habit of pooling their wishes. Somehow or other they must do this, if the play is to go on; maybe it will not, but there is no Jack, in or out of the box, who can come to straighten the game.
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Science can be introduced to children well or poorly. If poorly, children can be turned away from science; they can develop a lifelong antipathy; they will be in a far worse condition than if they had never been introduced to science at all.
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Poorly Lived and Poorly Died Poor buried and no one Cried
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You are rewarding a teacher poorly if you remain always a pupil.
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Poorly written novels--no matter how pious and edifying the behavior of the characters--are not good in themselves and are therefore not really edifying.
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It is the way of words to be inadequate. Take for example the word of words - 'communication' - how poorly it stands for the concept it is supposed to represent: The linkage of tow minds. Even if I can conceive the wonder, I cannot articulate It. Or 'articulation' - putting ideas into sounds. There are 61 words in this thought…
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Cats are notoriously sore losers. Coming in second best, especially to someone as poorly coordinated as a human being, grates their sensibility.
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I concluded that I was skilled, however poorly, at only one thing: marriage. And so I set about the business of selling myself and two childre...
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I come from a profession which has suffered greatly because of the lack of civility. Lawyers treat each other poorly and it has come home to haunt them. The public will not tolerate a lack of civility.
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Leaders are visionaries with a poorly developed sense of fear and no concept of the odds against them.
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Sexuality poorly repressed unsettles some families; well repressed, it unsettles the whole world.
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It was heartbreaking watching them play as poorly as they did, unfortunately. But I just got on with my game and seeing the shots I wanted to hit.
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The mouth obeys poorly when the heart murmurs.
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Well married a person has wings, poorly married shackles.
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He who leaves nothing to chance will do few things poorly, but he will do few things.
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Anything worth doing is worth doing poorly until you learn to do it well.
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Pay beforehand if you would have your work poorly done.
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Those who say truth is stranger than fiction have wasted their time on poorly written fiction.
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