Change is needed. Thirty years of experience with subcutaneous xenografts, human tumors implanted under the skin of the mouse, have satisfied few because so many drugs that cure cancer in these mice fail to help humans. A 2004 analysis in the Journal of the American Medical Association showed that only 3.8% of patients in phase I cancer drug trials between 1991 and 2002 achieved an objective clinical response — and the response rate is declining. Almost all drugs tried in humans work against subcutaneous xenografts in mice. “How many more negative data do you want? It’s very depressing.”
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Tentative efforts lead to tentative outcomes. Therefore, give yourself fully to your endeavors. Decide to construct your character through excellent actions and determine to pay the price of a worthy goal. The trials you encounter will introduce you to your strengths. Remain steadfast...and one day you will build something that endures, something worthy of your potential.
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'The drugs Prednisone and Vincristine are often hailed as 'curing' childhood leukemia. Both drugs were rejected by the US National Cancer Institute as 'useless' on the basis of animal tests. Prednisone was developed as a result of clinical observation of the effects of adrenal extract. Vincristine is an alkaloid of 'Vincra Rosea', a type of periwinkle plant, and extracts of periwinkle were used in the Roman Empire to 'dry tumours' (Pliny). They were eventually brought to clinical trials. The children cured of leukemia owe their lives to clinical observations and trials - and not to the animal 'model'.'
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Large families are going to go through financial trials, but it has really shaped my children. They learn how to share, how to communicate and how to compromise earlier.
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There are, however, people in this world who seldom pick up a newspaper, people who, when watching television, sneer in displeasure and change channels at the first glimpse of an anchorperson. While such willfully uninformed citizens are rare, emerging from seclusion only to serve on juries in trials of great national significance, they do exist.
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The pursuit of peace and progress cannot end in a few years in either victory or defeat. The pursuit of peace and progress, with its trials and its errors, its successes and its setbacks, can never be relaxed and never abandoned.
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Friendship is held to be the severest test of character. It is easy, we think, to be loyal to a family and clan, whose blood is in your own veins. Love between a man and a woman is founded on the mating instinct and is not free from desire and self-seeking. But to have a friend and to be true under any and all trials is the mark of a man!
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For 39 agents with both xenograft data and Phase II clinical trials results available, in vivo activity in a particular histology in a tumour model did not closely correlate with activity in the same human cancer histology, casting doubt on the correspondence of the pre-clinical models to clinical results.
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The point about it is that if you're pointed toward some kind of goodness, some kind of light, something positive, you find your way through these trials and tribulations, ... I've basically dedicated my whole lyrical life to people's ability to cope with the struggle because I do believe there is a struggle. And I don't mean it in a negative sense. I just mean it in a realistic sense. Nothing is greater than staying right on the positive, but sometimes life can have a way of just pulling you back and dragging you a bit.
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As an adolescent ... I was convinced that France would have to go through gigantic trials, that the interest of life consisted in one day rendering her some signal service and that I would have the occasion to do so.
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From the beginning of our history the country has been afflicted with compromise. It is by compromise that human rights have been abandoned. I insist that this shall cease. The country needs repose after all its trials; it deserves repose. And repose can only be found in everlasting principles.
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Trials, temptations, disappointments -- all these are helps instead of hindrances, if one uses them rightly. They not only test the fiber of character but strengthen it. Every conquering temptation represents a new fund of moral energy. Every trial endured and weathered in the right spirit makes a soul nobler and stronger than it was before.
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From the beginning of our history the country has been afflicted with compromise. It is by compromise that human rights have been abandoned. I insist that this shall cease. The country needs repose after all its trials it deserves repose. And repose can only be found in everlasting principles.
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Here is the answer which I will give to President Roosevelt... We shall not fail or falter we shall not weaken or tire. Neither the sudden shock of battle nor the long-drawn trials of vigilance and exertion will wear us down. Give us the tools and we will finish the job.
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Here is the answer which I will give to President Roosevelt... We shall not fail or falter; we shall not weaken or tire. Neither the sudden shock of battle nor the long-drawn trials of vigilance and exertion will wear us down. Give us the tools and we will finish the job.
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Now life is the only art that we are required to practice without preparation, and without being allowed the preliminary trials, the failures ...
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A gem cannot be polished without friction, nor a man perfected without trials.
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A gem is not polished without rubbing, nor a man perfected without trials.
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2 Thessalonians 1:4:
Therefore, among God's churches we boast about your perseverance and faith in all the persecutions and trials you are enduring.
(NIV)
And this is a cause of our mentioning you with pride among the churches (assemblies) of God for your steadfastness (your unflinching endurance and patience) and your firm faith in the midst of all the persecutions and crushing distresses and afflictions under which you are holding up.
(AMP)
So that we ourselves glory in you in the churches of God for your patience and faith in all your persecutions and tribulations that ye endure:
(KJV)
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When we borrow trouble, and look forward into the future and see what storms are coming, and distress ourselves before they come, as to how we shall avert them if they ever do come, we lose our proper trustfulness in God. When we torment ourselves with imaginary dangers, or trials, or reverses, we have already parted with that perfect love which casteth out fear.
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…some findings in colon cancer mice, which were very good models, actually led to clinical trials in humans which resulted in an increase in cancer.
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Given that many of these investigational anticancer drugs eventually fail, the animal models on which clinical trials are predicated must at best be limited in power, and at worst wildly inaccurate.
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A man who dreads trials and difficulties cannot become a revolutionary. If he is to become a revolutionary with an indomitable fighting spirit, he must be tempered in the arduous struggle from his youth. As the saying goes, early training means more than late earning.
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I believe, with abiding conviction, that this people-nurtured by their deep faith, tutored by their hard lessons, moved by their high aspirations-have the will to meet the trials that these times impose.
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Old age is not a disease- it is strength and survivorship, triumph over all kinds of vicissitudes and disappointments, trials and illnesses.
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John 16:33:
'I have told you these things, so that in me you may have peace. In this world you will have trouble. But take heart! I have overcome the world.'
(NIV)
I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]! For I have overcome the world. [I have deprived it of power to harm you and have conquered it for you.](AMP)
These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world.
(KJV)
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... money trials are not the hardest, and somehow or other, they are always overcome.
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We do trials in people because animal models do not predict what will happen in humans.
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We could hardly believe that after so many ordeals, after all the trials of modern skepticism, there was still so much left in our souls to destroy.
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When we put all the trials together we were hopeful of validating a cancer-protective effect, but we ended up not finding any.
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