The institution of marriage in all societies is a pattern within which the strains put by civilization on males and females alike must be resolved, a pattern within which men must learn, in return for a variety of elaborate rewards, new forms in which sexual spontaneity is still possible, and women must learn to discipline their receptivity to a thousand other considerations.
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Here is an artificial city which has been pumped up under forced draught, inflated like a balloon, stuffed with rural humanity like a goose with corn...endeavoring to eat up this too rapid avalanche of anthropoids, the sunshine metropolis heaves and strains, sweats and becomes pop-eyed, like a young boa constrictor trying to swallow a goat. It has never imparted an urban character to its incoming population for the simple reason that it has never had any character to impart. On the other hand, the place has the manners, culture and general outlook of a huge country village.
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When a damp/ Fell round the path of Milton, in his hand/ The thing became a trumpet; whence he blew/ Soul-animating strains - alas, too few!
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Most of us think ourselves as standing wearily and helplessly at the center of a circle bristling with tasks, burdens, problems, annoyance, and responsibilities which are rushing in upon us. At every moment we have a dozen different things to do, a dozen problems to solve, a dozen strains to endure. We see ourselves as overdriven, overburdened, overtired. This is a common mental picture and it is totally false. No one of us, however crowded his life, has such an existence. What is the true picture of your life? Imagine that there is an hour glass on your desk. Connecting the bowl at the top with the bowl at the bottom is a tube so thin that only one grain of sand can pass through it at a time. That is the true picture of your life, even on a super busy day, The crowded hours come to you always one moment at a time. That is the only way they can come. The day may bring many tasks, many problems, strains, but invariably they come in single file. You want to gain emotional poise? Remember the hourglass, the grains of sand dropping one by one.
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The use of inbred strains as test animals can be further questioned on the basis that they often develop spontaneous tumors in organs where cancers are not frequent in humans. For example, incidences of mouse liver tumors in 2-yearold B6C3F1 mice has ranged from 17.8 to 46.9 percent. In contrast, the death rate from liver cancer in the United States is about 0.005 percent.
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There are marked differences in carcinogenicity across sexes, strains and species. Often, the-same chemical will cause one kind of cancer in one experiment and another kind in another experiment Indeed, the most hard-bitten advocates of animal experiments do not claim to be able to predict which organ will be affected in humans by a chemical that is carcinogenic in animals.
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Just as a prism of glass miters light and casts a colored braid, a garden sings sweet incantations the human heart strains to hear. Hiding in every flower, in every leaf, in every twig and bough, are reflections of the God who once walked with us in Eden.
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It has been conventional practice to test potential carcinogens using highly inbred strains of rodents. The rationale was the supposed superior reproducibility of results compared with those obtained from wild-type animals. However, that assumption can be questioned. At least three examples of genetic drift of inbred strains can be cited... Lifetime expectation [in an inbred strain of mice] of developing one or another form of neoplasm ['spontaneous tumour'] had risen from 10 to 80 percent.
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Listen, can you hear it Spring's sweet cantata. The strains of grass pushing through the snow. The song of buds swelling on the vine. The tender timpani of a baby robin's heart. Spring.
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Even when there are common target sites for a given carcinogen, there are usually important differences, between man and animals, and between different species and strains of animals. These 'spontaneous' tumours in rats and mice... [vary] widely according to sex, strain, diet, conditions of maintenance, hormonal status, immunological status and latent virus infections.
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The standard carcinogenicity bioassay, which involves treating two rodent species for a minimum of 2 years, at a range of doses, is acknowledged to be an insensitive tool because of the background `noise' of spontaneous disease. Most strains of rat used in such studies have high incidence of pituitary and mammary tumours; some inbred rat strains frequently develop leukaemia or testicular tumours; mice strains show high incidence of malignant lymphomas and liver tumours.
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Results of the animal studies raise questions about the validity of federal regulations that are based on ad lib-fed inbred strains of rodents. Are humans to be regarded as behaving biochemically like huge, obese, inbred cancer-prone rodents?
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That a man can take pleasure in marching in formation to the strains of a band is enough to make me despise him. He has only been given his big brain by mistake; a backbone was all he needed.
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It is as queen of Canada that I am here. Queen of Canada and all Canadians, not just one or two ancestral strains.
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[Regarding tamoxifen, an anti-cancer drug] 'Experimentally, tamoxifen has carcinogenic potential. In some strains of rat, but not mouse or hamster, tamoxifen can cause liver cancers at doses as low as 5mg/kg per day... However, there are doubts about the correlation of [the results] with the risk of malignant disease even in rats, let alone in other rodents, mammals, or human beings. There are many uncertainties in extrapolating these experimental data from rats to women. The effect depends on bioavailability, hepatic [liver] blood flow, and hepatic [liver] metabolism to active genotoxic carcinogens, all of which differ enormously between rat and man.
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I think you will see a lot of strains develop in the political process that will result in violence everywhere in the country - but it's controllable, it's workable and it will lead to a much better future for these people.
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Living in the past is a dull and lonely business looking back strains the neck muscles, causes you to bump into people not going your way.
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He strains his conversation through a cigar.
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The institution of marriage in all societies is a pattern within which the strains put by civilization on males and females alike must be reso...
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