Change is needed. Thirty years of experience with subcutaneous xenografts, human tumors implanted under the skin of the mouse, have satisfied few because so many drugs that cure cancer in these mice fail to help humans. A 2004 analysis in the Journal of the American Medical Association showed that only 3.8% of patients in phase I cancer drug trials between 1991 and 2002 achieved an objective clinical response — and the response rate is declining. Almost all drugs tried in humans work against subcutaneous xenografts in mice. “How many more negative data do you want? It’s very depressing.”
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There is no mystery, at least not the kind you want. In real life there are no fogbound moors or clues on matchbooks or fifth columnists waiting to be unmasked. it would be nice if here were, because then there would be solutions to things in life, but it doesn't always work that way. Everyone likes a good detective story. I went through my Hammett phase in college. I think the attraction is, in life our mysteries aren't exciting. You know They're just intractable and depressing and enervating. Like, why do we always hurt the ones we love. Where does the money go ...in a detective story, at least the universe makes sense. It was him. He did it. The natural order is disturbed, but the beauty of it is that it's restored again.
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Now it's time for one of my favorite cartoons. It's a sad, depressing story about a pathetic coyote who spends every waking moment in the futile persuit of a sadistic roadrunner, who mocks him and laughs at him as he is repeatedly crushed and maimed. I hope you enjoy it!
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You should never pick up a newspaper when you're feeling good, because every newspaper has a special department, called the Bummer Desk, which is responsible for digging up depressing front-page stories with headlines like DOORBELL USE LINKED TO LEUKEMIA
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I'm tired of playing worn-out depressing ladies in frayed bathrobes. I'm going to get a new hairdo and look terrific and go back to school and...
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I hated school. Even to this day, when I see a school bus it's just depressing to me. The poor little kids.
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Perhaps nothing is so depressing an index of the inhumanity of the male-supremacist mentality as the fact that the more genial human traits are assigned to the underclass: affection, response to sympathy, kindness, cheerfulness.
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I was once thrown out of a mental hospital for depressing the other patients.
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Nothing is more depressing than the conviction that one is not a hero.
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I find nothing more depressing than optimism.
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It is depressing to hear the unfortunate or dying man jest.
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What may seem depressing or even tragic to one person may seem like an absolute scream to another person, especially if he has had between four and seven beers.
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There is too much fathering going on just now and there is no doubt about it fathers are depressing.
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It's depressing, drugs that worked really well in animals, really ought to have worked, and didn't have any efficacy in humans at all.
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The brotherhood of man is not a mere poet's dream: it is a most depressing and humiliating reality.
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