It is in fact hard to find a single, common solid neoplasm [cancer] where management and expectation of cure has been markedly affected by animal research. Most human cancers differ from the artificially produced animal model
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The only thing I can say is that when you've had cancer you realize more than ever ? even though you should probably realize it before ? how important raising money for research is. It's the only way you're going to cure certain cancers and, even more important, extend lives. It was 1999 when I was diagnosed. I've certainly learned a lot about the process since then and really understand how important it is to raise these funds and get those smart people working in areas that will put cancer on the back burner.
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The estimate made by NIOSH was 597 excess cancers per 10,000 workers having that same exposure... Instead of extra cancers predicted by NIOSH, workers had fewer cancers than expected...With trillions of dollars, loss of competitiveness, and jobs at stake, a searching review of the risk assessment methodology of the regulatory agencies is overdue.
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What we have come to consider as 'normal' illnesses of aging are really not normal. In fact, these findings indicate that the vast majority, perhaps 80 to 90%of all cancers, cardiovascular diseases, and other forms of degenerative illness can be prevented, at least until very old age, simply by adopting a plant-based diet.
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The use of inbred strains as test animals can be further questioned on the basis that they often develop spontaneous tumors in organs where cancers are not frequent in humans. For example, incidences of mouse liver tumors in 2-yearold B6C3F1 mice has ranged from 17.8 to 46.9 percent. In contrast, the death rate from liver cancer in the United States is about 0.005 percent.
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The in vitro cell line model was predictive for non-small cell lung cancer under the disease-oriented approach, for breast and ovarian cancers under the compound-oriented approach, and for all four tumor types together. The mouse allograft model was not predictive. The human xenograft model was not predictive for breast or colon cancers, but was predictive for non-small cell lung and ovarian cancers when panels of xenografts were used.
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Colonoscopy has proven to be an effective method for preventing colorectal cancer by detecting and removing polyps that have the potential to develop into colorectal cancer as well as finding early cancers that are more effectively treated.
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From a comparison of the results of the present study with those of other studies, one can draw the following conclusions: compounds that cause hepatomas (liver cancers) in mice, may not always be carcinogenic in rats, or if carcinogenic in both species, the compounds may have different primary target sites. The extrapolation of such results to define any risk to humans remains a troublesome problem.'-
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[Regarding tamoxifen, an anti-cancer drug] 'Experimentally, tamoxifen has carcinogenic potential. In some strains of rat, but not mouse or hamster, tamoxifen can cause liver cancers at doses as low as 5mg/kg per day... However, there are doubts about the correlation of [the results] with the risk of malignant disease even in rats, let alone in other rodents, mammals, or human beings. There are many uncertainties in extrapolating these experimental data from rats to women. The effect depends on bioavailability, hepatic [liver] blood flow, and hepatic [liver] metabolism to active genotoxic carcinogens, all of which differ enormously between rat and man.
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Warning is given not to carry over, without reservation, to man, the conclusions based on animal experiments. In monkeys none of the powerful carcinogens [of man] has been shown to produce cancers.
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Kidney cancer is one of the cancers that they don't have many treatment options for and everything is pretty much experimental.
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