In the U.S. NCI retrospective (2001), activity in at least 33% of models of a variety of histologies predicted for clinical activity in some disease. In the NCI of Canada retrospective (2003), generally similar conclusions were reached. It should be cautioned, however, that the drugs used in these studies were for the most part 'classic' cytotoxics. Whether 'targeted' therapeutics, such as signal transduction inhibitors, antiangiogenic, or stroma-modifying agents, would perform better or worse remains to be defined.
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All the big corporations depreciate their possessions, and you can, too, provided you use them for business purposes. For example, if you subscribe to the Wall Street Journal, a business-related newspaper, you can deduct the cost of your house, because, in the words of U.S. Supreme Court Chief Justice Warren Burger in a landmark 1979 tax decision: 'Where else are you going to read the paper? Outside? What if it rains?'
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Neither the doctrine of separation of powers, nor the need for confidentiality of high level communications, without more, can sustain an absolute, unqualified presidential privilege of immunity from judicial process under all circumstances. The President's need for complete candor and objectivity from advisers calls for great deference from the courts. However, when the privilege depends solely on the broad, undifferentiated claim of public interest in the confidentiality of such conversations, a confrontation with other values arises. Absent a claim of need to protect military, diplomatic or sensitive national security secrets, we find it difficult to accept the argument that even the very important interest in confidentiality of Presidential communications is significantly diminished by production of such material for in camera inspection with all the protection that a district court will be obliged to provide.
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Even when drugs with evidence of anticancer activity in preclinical in vivo models are given at their maximum tolerated doses, they frequently fail to produce useful activity in humans.
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The individual choice of garnishment of a burger can be an important point to the consumer in this day when individualism is an increasingly important thing to people.
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In summary, mouse xenograft models should not be viewed as ideal models for cancer drug development. Altered, nonhuman host stroma, poor predictive value when applied in an empirical sense, and questionable relation to the naturally occurring human disease are but a few features, which temper enthusiasm for their use.
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on being sued by Amarillo cattle ranchers for saying: 'I'm stopped. I'll never eat another burger'.
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There can be no assumption that today's majority is right and the Amish and others like them are wrong. A way of life that is odd or even erratic but interferes with no rights or interests of others is not to be condemned because it is different.
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It takes many ingredients to make Burger King great but... THE SECRET INGREDIENT IS OUR PEOPLE.
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I think it's unethical to take money for poor quality performance.
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We must have a program to learn the way out of prison.
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