In the second half of life the necessity is imposed of recognizing no longer the validity of our former ideals but of their contraries. Of perceiving the error in what was previously our conviction, of sensing the untruth in what was our truth, and of weighing the degree of opposition, and even of hostility, in what we took to be love.

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It is hard to know what you are talking about in mathematics, yet no one questions the validity of what you say. There is no other realm of discourse half so queer.

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I believe that history has shape, order, and meaning that exceptional men, as much as economic forces, produce change and that passe abstractions like beauty, nobility, and greatness have a shifting but continuing validity.

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Results of the animal studies raise questions about the validity of federal regulations that are based on ad lib-fed inbred strains of rodents. Are humans to be regarded as behaving biochemically like huge, obese, inbred cancer-prone rodents?

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Now, as a law directed against the mass of the nation has not the nature of a reasonable institution, so neither has it the authority: for in all forms of government the people is the true legislator; and whether the immediate and instrumental cause of the law be a single person or many, the remote and efficient cause is the consent of the people, either actual or implied ; and such consent is absolutely essential to its validity.

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The cruel experimenter cannot be allowed to have it both ways. He cannot, in the same breath, defend the scientific validity of vivisection on the grounds of the physical similarities between man and the other animals, and then defend the morality of vivisection on the grounds that men and animals are physically different. The only logical alternatives for him are to admit he is either pre-Darwinian or immoral.

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Indeed, I came to question the validity of a society that appeared more concerned with imposing its will than in inspiring respect. There seemed to me something grossly wrong with this -- 'We'll make you be good!' I was told, and I told myself, nobody should, would or could make me anything. And I proved it.

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The major problems of animal studies are the validity of cross-species comparisons and relevance to human disease.

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It is the duty of every citizen according to his best capacities to give validity to his convictions in political affairs.

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An ideal cannot wait for its realization to prove its validity.

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