The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.
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You say that at the time of the Congress, in 1765, The great mass of the people were zealous in the cause of America. The great mass of the people is an expression that deserves analysis. New York and Pennsylvania were so nearly divided, if their propensity was not against us, that if New England on one side and Virginia on the other had not kept them in awe, they would have joined the British. Marshall, in his life of Washington, tells us, that the southern States were nearly equally divided. Look into the Journals of Congress, and you will see how seditious, how near rebellion were several counties of New York, and how much trouble we had to compose them. The last contest, in the town of Boston, in 1775, between whig and tory, was decided by five against two. Upon the whole, if we allow two thirds of the people to have been with us in the revolution, is not the allowance ample? Are not two thirds of the nation now with the administration? Divided we ever have been, and ever must be. Two thirds always had and will have more difficulty to struggle with the one third than with all our foreign enemies.
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