It is so friendly so simply friendly and though inevitable not a sadness and though occurring not a shock.
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The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.
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I have always been amazed at the way an ordinary observer lends so much more credence and attaches so much more importance to waking events than to those occurring in dreams.... Man...is above all the plaything of his memory.
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In summary, mouse xenograft models should not be viewed as ideal models for cancer drug development. Altered, nonhuman host stroma, poor predictive value when applied in an empirical sense, and questionable relation to the naturally occurring human disease are but a few features, which temper enthusiasm for their use.
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The consequences of an act affect the probability of its occurring again.
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A good deal happens in a man's life that he isn't responsible for. Fortunate openings occur but it is safe to remember that such 'breaks' are occurring all the time, and other things being equal, the advantage goes to the man who is ready.
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Changes start occurring when budgets are cut.
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If the odds are a million to one against something occurring, chances are 50-50 it will.
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