Why the dog was ever considered as an appropriate animal for carcinogenicity testing is also not entirely clear... Despite the obvious problems of study design and interpretation, carcinogenicity tests in the dog, lasting 7 years, were requested by regulatory authorities from the late 1960s...One of the best known examples of the inappropriate use of the dog was the carcinogenicity testing of hormonal contraceptives. It is now understood that mammogenesis in the dog is very different from that in primates; quantitative and qualitative differences exist in the feedback control mechanisms, receptor content and behaviour, and target sensitivity and responsivity. As a result of this biological difference there was a high incidence of mammary tumours in long-term studies in dogs treated with progestagens/contraceptive steroids such as lynestrol. Ultimately pressure from the scientific community led, relatively recently, to the requirement for carcinogenicity studies in dogs being dropped.
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To a pitcher, a base hit is the perfect example of negative feedback.
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Champions know that success is inevitable that there is no such thing as failure, only feedback. They know that the best way to forecast the future is to create it.
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A lot of people recognize me or feel that they know me. A lot of times when I speak, they recognize my voice. It's fun, it's exciting. It's always good feedback.
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The directors felt like they should get feedback from residents before making a commitment to contribute. I don't think we anticipated getting this sort of response. It was a pleasant surprise.
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Champions know that success is inevitable; that there is no such thing as failure, only feedback. They know that the best way to forecast the future is to create it.
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Feedback is the breakfast of champions.
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I get a lot of inspiration from the audience feedback to our live shows.
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