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Alkaloid Quotations

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'The drugs Prednisone and Vincristine are often hailed as 'curing' childhood leukemia. Both drugs were rejected by the US National Cancer Institute as 'useless' on the basis of animal tests. Prednisone was developed as a result of clinical observation of the effects of adrenal extract. Vincristine is an alkaloid of 'Vincra Rosea', a type of periwinkle plant, and extracts of periwinkle were used in the Roman Empire to 'dry tumours' (Pliny). They were eventually brought to clinical trials. The children cured of leukemia owe their lives to clinical observations and trials - and not to the animal 'model'.'

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