[adj] mentally or physically unfit [adj] grievously affected especially by disease
ill, impaired, sick, stricken, unfit
abashed, agitated, agonized, bent, beset, boiled, bombed, boozy, bothered, canned, cast down, chagrined, chapfallen, cockeyed, cockeyed drunk, confused, convulsed, crocked, crocko, crucified, discomfited, discomforted, discomposed, disconcerted, disquiete