Our goals were to address the following, ... Does ascorbate in pharmacologic concentrations kill cancer cells, but not normal cells, using conditions that mimic IV use and a clinically relevant time course? Is action dependent on extracellular ascorbate, intracellular ascorbate, or both? If effective, what are the mechanisms? Can ascorbate be delivered to tissues without harm? Are there implications for other diseases?
|
Since its inception 25 years ago, EPA [the US Environmental Protection Agency] has applied the same logic to hundreds of other substances, extrapolating from high levels in animal studies to arrive at acceptable levels for humans. But that approach, say scientists both inside and outside the federal government, may no longer be the best way to safeguard public health...EPA's new emphasis on molecular data is based on a growing body of evidence that extrapolations from megadoses can provide a misleading picture of the effects of low-level exposure. Chloroform is a good example. EPA's current strict standards were derived from a study in which mice developed liver tumors after exposure to massive daily doses of chloroform pumped into their stomachs over several months. However, those findings may not be relevant to human exposures, according to a paper picked by the Society of Toxicology as the best published last year in its journal.
|
... if art speaks clearly about something relevant to people's lives it can change the way they perceive reality.
|
Increasingly in recent times we have come first to identify the remedy that is most agreeable, most convenient, most in accord with major pecuniary or political interest, the one that reflects our available faculty for action; then we move from the remedy so available or desired back to a cause to which that remedy is relevant.
|
It is not altogether wrong to say that there is no such thing as a bad photograph -- only less interesting, less relevant, less mysterious ones.
|
The intellectual equipment needed for the job of the future is an ability to define problems, quickly assimilate relevant data, conceptualize and reorganize the information, make deductive and inductive leaps with it, ask hard questions about it, discuss findings with colleagues, work collaboratively to find solutions and then convince others.
|
The fathers of the field had been pretty confusing: John von Neumann speculated about computers and the human brain in analogies sufficiently wild to be worthy of a medieval thinker, and Alan Turing thought about criteria to settle the question of whether machines can think, a question of which we now know that it is about as relevant as the question of whether submarines can swim.
|
Debugging tips from the Master, Sherlock Holmes:
'It is a capital mistake to theorize before one has data. Insensibly one begins to twist facts to suit theories instead of theories to suit facts.'
'As a rule, the more bizarre a thing is, the less mysterious it proves to be.'
'Perhaps I have trained myself to see what others overlook.'
'There is nothing more deceptive than an obvious fact.'
'Chance has put in our way a most singular and whimsical problem, and its solution is its own reward.'
'I am glad of all details, whether they seem to you to be relevant or not.'
|
May we agree that private life is irrelevant? Multiple, mixed, ambiguous at best -- out of it we try to fashion the crystal clear, the singular, the absolute, and that is what is relevant; that is what matters.
|
I hope that no American ... will waste his franchise and throw away his vote by voting either for me or against me solely on account of my religious affiliation. It is not relevant.
|
But I wouldn't like it to be a kind of political stunt ... I hope it is relevant to the case. If it is not relevant to the case, and they just want to make a political show of it, I don't think it is being very fair,
|
Cambridge is thriving and Britain is working. We have been telling people - 'if you value it, vote for it' - and this is particularly relevant in Cambridge.
|
We try to make choices and do things with our career that make a positive impact. We want to have long-lasting careers, but we don't want to have to give in to the industry. We want to stand for what's right, and you can do that and still be relevant and still matter.
|
But it seemed to me that as soon as you have computer storage you could put every point you wanted in - make the ones that are less relevant to your central topic, further away or allow the central topic to move as the reader proceeded.
|
Abstraction is a mental process we use when trying to discern what is essential or relevant to a problem; it does not require a belief in abstract entities.
|
Christianity is either relevant all the time or useless anytime. It is not just a phase of life; it is life itself.
|
The United States is, at the moment, not well prepared to manage an [emergency] evacuation of this sort in the relevant time frame,
|
How do you define God? Like this. A God I could understand, at least potentially, was infinitely more interesting and relevant than one that defied comprehension.
|
How do you define God Like this. A God I could understand, at least potentially, was infinitely more interesting and relevant than one that defied comprehension.
|
I hope that no American will waste his franchise and throw away his vote by voting either for me or against me solely on account of my religious affiliation. It is not relevant.
|
Politics is the art of postponing decisions until they are no longer relevant.
|
Success is relevant to coping with obstacles... But no problem is ever solved by those, who, when they fail, look for someone to blame instead of something to do.
|