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There are marked differences in carcinogenicity across sexes, strains and species. Often, the-same chemical will cause one kind of cancer in one experiment and another kind in another experiment Indeed, the most hard-bitten advocates of animal experiments do not claim to be able to predict which organ will be affected in humans by a chemical that is carcinogenic in animals.

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[Regarding the difficulties of applying animal results to humans] 'There turn out to be many different ways to measure this difference [in size]. For example, a man weighs 2800 times as much as a mouse, eats 300 times as much per day and lives 40 times as long. Which factor should be used to rescale the dose?

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[Regarding animal carcinogenicity tests on saccharin] Published risk estimates, starting from the same animal data but using various [statistical] models, differ by factors of over 5,000,000.

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