Books, books, books had found the secret of a garret-room piled high with cases in my father's name; Piled high, packed large, --where, creeping in and out among the giant fossils of my past, like some small nimble mouse between the ribs of a mastodon, I nibbled here and there at this or that box, pulling through the gap, in heats of terror, haste, victorious joy, the first book first. And how I felt it beat under my pillow, in the morning's dark. An hour before the sun would let me read! My books!
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I love Mickey Mouse more than any woman I've ever known.
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Mickey Mouse to a three-year-old is a six-foot-tall RAT!
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I love Mickey Mouse more than any woman I have ever known.
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Change is needed. Thirty years of experience with subcutaneous xenografts, human tumors implanted under the skin of the mouse, have satisfied few because so many drugs that cure cancer in these mice fail to help humans. A 2004 analysis in the Journal of the American Medical Association showed that only 3.8% of patients in phase I cancer drug trials between 1991 and 2002 achieved an objective clinical response — and the response rate is declining. Almost all drugs tried in humans work against subcutaneous xenografts in mice. “How many more negative data do you want? It’s very depressing.”
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The fundamental problem in drug discovery for cancer is that the model systems are not predictive at all. ancer research at Merck Research Laboratories in West Point, Pennsylvania…Researchers blamed the failures on the fact that the drugs were being tested against mouse, not human, tumors… the xenograft tumors don't behave like naturally occurring tumors in humans – they don't spread to other tissues, for example. Thus, drugs tested in the xenografts appeared effective but worked poorly in humans.
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Coleridge says that to bait a mouse-trap is as much as to say to the mouse, 'Come and have a piece of cheese,' and then, when it accepts the invitation, to do it to death is a betrayal of the laws of hospitality.
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If you can dream it, you can do it. Always remember this whole thing was started by a mouse.
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1-3 Butadiene, an important industrial chemical and a common environmental air pollutant, has been shown to be a weak carcinogen in the rat, but a potent carcinogen in the B6C3F1 mouse. This species difference makes risk extrapolation to humans difficult, and the underlying mechanism must be clarified before meaningful risk extrapolation to humans can be made.
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Mountains will be in labour, and the birth will be an absurd little mouse.
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Mountains will go into labour, and a silly little mouse will be born.
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The white youth of today have begun to react to the fact that the American Way of Life is a fossil of history. What do they care if their old baldheaded and crew-cut elders don't dig their caveman mops? They couldn't care less about the old, stiff-assed honkies who don't like their new dances: Frog, Monkey, Jerk, Swim, Watusi. All they know is that it feels good to swing to way-out body-rhythms instead of dragging across the dance floor like zombies to the dead beat of mind-smothered Mickey Mouse music.
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Tank: Here you go, buddy: 'Breakfast of Champions.'
Mouse: If you close your eyes, it almost feels like you're eating runny eggs.
Apoc: Yeah, or a bowl of snot.
Mouse: Do you know what it really reminds me of? Tasty Wheat. Did you ever eat Tasty Wheat? Switch: No, but technically, neither did you.
Mouse: That's exactly my point. Exactly! Because you have to wonder: how do the machines know what Tasty Wheat tasted like? Maybe they got it wrong. Maybe what I think Tasty Wheat tasted like actually tasted like oatmeal, or tuna fish. That makes you wonder about a lot of things. You take chicken, for example. Maybe they couldn't figure out what to make chicken taste like, which is why chicken tastes like everything!
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I was looking for an American symbol. A Coca-Cola bottle or a Mickey Mouse would have been ridiculous, doing anything with the American flag would have been insulting, and Cadillac hub caps were just too uncomfortable. (speaking about the dress she wore made of American Express Cards)
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She sits composedly sentinel, with paws tucked under her, a good part of her days at present by some ridiculous little hole, the possible entry of a mouse.
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... numerous chemicals have been found to have potential toxicity/carcinogenicity in rat or mouse, which, we are reasonably certain, have little or no potential hazard in man. The reason for this is again species differences, for the biological defence mechanism which protects against toxic chemicals is most highly evolved in man, who therefore generally has a higher resistance to chemical toxicity and carcinogenicity than have rodents and other species.
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An elephant is a mouse, built to government specifications.
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The in vitro cell line model was predictive for non-small cell lung cancer under the disease-oriented approach, for breast and ovarian cancers under the compound-oriented approach, and for all four tumor types together. The mouse allograft model was not predictive. The human xenograft model was not predictive for breast or colon cancers, but was predictive for non-small cell lung and ovarian cancers when panels of xenografts were used.
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If you are neutral in situations of injustice, you have chosen the side of the oppressor. If an elephant has its foot on the tail of a mouse and you say that you are neutral, the mouse will not appreciate your neutrality.
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The use of inbred strains as test animals can be further questioned on the basis that they often develop spontaneous tumors in organs where cancers are not frequent in humans. For example, incidences of mouse liver tumors in 2-yearold B6C3F1 mice has ranged from 17.8 to 46.9 percent. In contrast, the death rate from liver cancer in the United States is about 0.005 percent.
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Hitchhiker No No, no, not 6 I said 7. Nobody's comin' up with 6. Who works out in 6 minutes You won't even get your heart goin, not even a mouse on a wheel. Ted That -- good point. Hitchhiker 7's the key number here. Think about it. 7-Elevens. 7 doors. 7, man, that's the number. 7 chipmunks twirlin' on a branch, eatin' lots of sunflowers on my uncle's ranch. You know that old children's tale from the sea. It's like you're dreamin' about Gorgonzola cheese when it's clearly Brie time, baby. Step into my office. Ted Why Hitchhiker 'Cause you're fired
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In baiting a mouse-trap with cheese, always leave room for the mouse.
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In summary, mouse xenograft models should not be viewed as ideal models for cancer drug development. Altered, nonhuman host stroma, poor predictive value when applied in an empirical sense, and questionable relation to the naturally occurring human disease are but a few features, which temper enthusiasm for their use.
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You can drop a mouse down a thousand-yard mine shaft and, on arriving at the bottom, it gets a slight shock and walks away. A rat would probably be killed, though it can fall safely from the eleventh story of a building, a man is broken, a horse splashes.
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Armed with a wiggle and a Minnie Mouse squawk, she is coarse and charmless.
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Arithmetic is being able to count up to twenty without taking off your shoes.
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Mickey Mouse is a rat.
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When the mouse laughs at the cat there is a hole nearby.
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The drive to resist compulsion is more important in wild animals than sex, food, or water. He found that captive white-footed mice spent inordinate time and energy just resisting experimental manipulation. If the experimenters turned the lights up, the mouse spent his time turning them down. If the experimenter turned the lights down, the mouse turned them up. The drive for competence or to resist compulsion is a drive to avoid helplessness.
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For example, the control incidence of mouse liver tumour varies between 0 and 58% in 41 NTP [National Toxicology Program] bioassays where these tumours are induced by a test chemical.
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