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Assay Quotations

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There are many unresolved problems in the standard bio-assay, including... how to account for inter-species and intra-species differences in metabolism and pharmacokinetics.

+Fav | Go to Quote / Comment | Omenn and Lave |

Risk assessment policy that relies solely on screening bio-assay results from the most sensitive species is not based on scientific principles. Neither is it credible or reliable.

+Fav | Go to Quote / Comment | Dr Vernon Houk |

The lifetime feeding study of mice and rats appears to have less than a 50% probability of finding known human carcinogens. On the basis of probability theory, we would have been better off to toss a coin...The `definitive bioassay for carcinogenesis' as now designed has never been subjected to proper validation as an assay for human carcinogens. At attempt made in this paper to examine the literature suggests that it may have an unacceptably high false negative rate and that it produces so many contradictory answers as to suggest a very poor specificity.

+Fav | Go to Quote / Comment | Dr David Salsburg |